The use of platelet rich plasma for acute muscle tears: Systematic review and meta-analysis of current evidence.
DOI:
https://doi.org/10.15417/issn.1852-7434.2020.85.1.983Keywords:
plasma rico en plaquetas, factores de crecimiento, lesiones musculares, medicina regenerativa, biológicosAbstract
Introduction
Muscle tear is the most frequent type of injury in sports activities. An interest has been observed in the search for conditions that reduce and improve the healing time. The use of platelet-rich plasma (PRP) has grown in popularity in recent years, but such popularity was not accompanied by sufficient scientific support to back up its effectiveness. This study aims to summarize, analyze and synthesize published data to clarify the effects of PRP use on muscle tears through systematic review and meta-analysis.
Material and methods
Systematic review of the literature on the use of PRP for the treatment of muscle injuries was carried out. A meta-analysis was conducted to evaluate the effects of PRP.
Results
A total of 7 articles met the inclusion criteria for analysis. Six randomized controlled trials and one cohort study. The overall time to return to sports in PRP treatment was a mean of 29 days (range, 10 to 50.9 days). In the control groups was a mean of 35.4 days (range, 22 to 52.8 days). Meta-analysis (5 of the 7 articles) demonstrated a significant difference in earlier return to sports with the use of PRP when compared to conventional therapy (-7.80 days; p= 0.007). No difference in recurrence rate were reported.
Conclusion
Meta-analysis demonstrated a favorable effect of PRP when compared to conventional therapy. However, our analysis demonstrated significant study heterogeneity. Thus, our findings should be interpreted with caution. We still can not recommend the use of PRP for the treatment of muscle muscles.
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References
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